Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV

Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV

Innate immunity is key to the fight against the daily onslaught from viruses that our bodies are subjected to. Essential to this response are the interferons (IFNs) that prime our cells to block viral pathogens. Recent evidence suggests that the Type III (λ) IFNs are intimately associated with the immune response to hepatitis C virus (HCV) infection. Genome-wide association studies have identif...

Interferon lambda 4 signals via the IFMλ receptor to regulate antiviral activity against HCV and coronaviruses

I have received the two reports on your paper, which I have provided below. Bottom line is that a lot of work would be needed for consideration at the EMBO Journal see referee #2. If you would be able to fully address the concerns raised with the inclusion of experimental data then we would be interested, but if you can't extend the analysis as needed then it is in your best interest to seek ra...

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses.

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The expression of IFNλ4 is correlated with both poor spontaneous clearance of hepatitis C virus (HCV) and poor response to treatment with type I interferon. Here, we show that the IFNL4 gene encodes an active type III inter...

Industry in the fight against COVID-19 crisis

The Jurisprudential Foundations of the Fight against Terrorism and Iran's Efforts in this Regard

Terrorism is an act whose nature and outcome is violence and fear. Regardless of the different forms of the realization of this act in the past, it has taken new forms in the contemporary era due to the advancement of sciences and technologies. To face this phenomenon, then, it is necessary to foresee and apply appropriate and favorable measures. As a victim of internal and external terrorism, ...